Delbert M. Shankel Structural Biology Center - Home of the High Throughput Screening Laboratory
High Throughput Screening Laboratory at KU
High throughput screening of large chemical libraries of compounds is a proven way to identify novel chemical entities that target a biological system of interest. In order to have this technology available to biomedical researchers in Kansas and beyond, the KU High Throughput Screening Laboratory (KU-HTSL) was established in 2002 at the University of Kansas with support from the COBRE Center for Cancer Experimental Therapeutics (NIH 8P30GM103495), the State of Kansas and the University.
The KU-HTS lab also serves as the Infectious Diseases Assay Development Laboratory (IDAD) that is supported in part by the NIH CoBRE in Chemical Biology for Infectious Disease (CBID) grant (NIH P20GM113117). The Chemical Biology for Infectious Disease (CBID) program provides investigators with complete financial support for research activities, mentoring, and access to the three core lab services: Infectious Disease Assay development (IDAD) Core, the Computational Chemical Biology Core (CCB) and the Synthetic Chemical Biology Core (SCB). The CoBRE pilot grant program enables junior and senior investigators to generate preliminary data for submission of competitive grant applications, develop new technologies, and/or achieve other goals as defined by the PI that will better position the institution to conduct biomedical research.
The KU-HTS lab is also a shared resource for the KU Cancer Center (KUMC) and is partly supported by the University of Kansas Medical Center (KUMC) NCI Cancer Center Support grant (P30 CA16852407). The HTS laboratory provides assay development and screening (drug repurposing, diversity and combination screens) support for cancer focused projects as a part of the KU Cancer Center's Drug Discovery, Delivery & Experimental Therapeutics (D3ET) Research Program, which provides an infrastructure built with a pharma perspective in accelerating drug discovery efforts.
The KU-HTSL is a fee-for-service facility dedicated to providing academia and nonprofit institutions, as well as the biotech and pharmaceutical industry, with exceptional quality services at the lowest cost structure. We partner with the investigators collaboratively to expedite their probe and drug discovery efforts and serve as a uniquely qualified reference facility with high throughput screening instrument manufacturers as well as reagent kit developers and manufacturers. We strive to establish an enduring relationship with our customers and collaborators in addressing their drug discovery needs pertaining to target identification and validation, assay development, high throughput screening, hit confirmation, data mining and medicinal chemistry to facilitate hit to lead development.
Please come and talk to us.
|Anuradha Roy, Ph.D.